The five abstract titles include:
- BPM31510 synergizes gemcitabine efficacy in pancreatic adenocarcinoma via mechanism independent of its anti-Warburg influence on metabolism.
- BPM31510-induced alteration in Complex II activity is functionally linked to cell death activation pathway in a preclinical model of triple-negative breast cancer.
- Project Survival: Interrogative Biology® platform mediated discovery of molecular markers for detection, stratification and outcomes in pancreatic cancer.
- The anti-Warburg agent BPM31510 arbitrates fatty acid metabolism in eliciting an anticancer response.
- Molecular drivers of endothelial hypoxic adaption during angiogenesis deciphered using the Berg Interrogative Biology® platform.
BERG, the namesake of Chairman and Co-founder Carl E. Berg, utilizes artificial intelligence as a foundation to creating the next generation of drugs and diagnostics. Its revolutionary drug, BPM31510, is one of the first cancer drugs guided in development by artificial intelligence. It works by reprogramming the metabolism of cancer cells, or reversing the Warburg effect, re-teaching them to undergo cell death. Data from preclinical and human trials indicate that treatment with BPM31510 as a single-agent leads to tumor regression and clinical benefits and increases antitumor activity in combination with chemotherapy agents.
BERG’s Interrogative Biology® Platform looks at patients by “phenotype” rather than “genotype” by integrating molecular data directly from a patient with clinical and demographic information to learn predictive patterns. The platform has the potential to provide physicians with actionable data to recommend efficient and safe treatment pathways, insurance companies with health economics analyses to develop more relevant formulary, and governments with a data ecosystem for financial modeling of healthcare needs of the population
Full abstracts of the posters are available on the AACR website.
BERG, is a biopharmaceutical company with divisions that include Analytics, Pharma, Biosystems and Diagnostics. Our research focus seeks to understand how alterations in metabolism relate to disease onset. We have uncovered key insight into metabolic control factors and namely into underlying elements in the Warburg Hypothesis. The company has a deep pipeline of early-stage technologies in CNS diseases and metabolic diseases that complement its late-stage clinical trial activity in cancer and prevention of chemotoxicity. Armed with the use of the discovery platform that translates biological output into viable therapeutics and a robust biomarker library, Berg is poised to realize its pursuit of a healthier tomorrow. For additional information, please visit www.berghealth.com.
About the BERG Interrogative Biology™ Platform
BERG’s application of machine-learning (Artificial Intelligence) in biology and medicine allows for a combination of systems biology and systems engineering leading to well defined answers on human health. The BERG Interrogative Biology® platform integrates molecular data directly from a patient with clinical and demographic information to learn predictive patterns. The platform has the potential to provide the physician with actionable information to recommend efficient and safe treatment pathways, insurance companies with health economics analyses to develop more relevant formulary and governments with a data ecosystem for financial modeling of healthcare needs of the population