Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017, May et al.- BERG collaborates with Joslin Diabetes Center, Boston, to characterize the lipidome of white and brown adipose tissue in response to exercise Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A.…

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

Journal of Extracellular Vesicles, 2016, Haraszti et al – BERG collaborates with UMASS School of Medical to characterize the lipidome of exosomes and microvesicles Authors: Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, and Anastasia Khvorova Exosomes and microvesicles represent a novel biological mechanism of communication between…

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data Authors: Vijetha Vemulapalli, Jiaqi Qu, Jeonifer M. Garren, Leonardo O. Rodrigues, Michael A. Kiebish, Rangaprasad Sarangarajan, Niven R. Narain, Viatcheslav R. Akmaev Artificial Intelligence in Medicine 2016, Vemulapalli et al. – bAIcis™, the Interrogative Biology® AI engine discovers a novel link between…

Identification and preliminary assessment of FLNA, FLNB, and KRT19 as potential biomarkers for prostate cancer

Future Science Open Access 2016, Narain et al- Berg’s Interrogative Biology platform discovers a novel biomarker panel for prostate cancer detection in blood samples Authors: Niven R Narain, Anne R Diers, Arleide Lee, Socheata Lao, Joyce Y Chan, Sally Schofield, Joe Andreazi, Rakibou Ouro-Djobo, Joaquin J Jimenez, Tracey Friss, Nikunj Tanna, Aditee Dalvi, Sihe Wang, Dustin Bunch, Yezhou Sun, Wenfang Wu, Khampaseuth Thapa, Stephane Gesta, Leonardo O Rodrigues, Viatcheslav R Akmaev, Vivek K Vishnudas & Rangaprasad Sarangarajan Current…

Metabolomics: Bridging the Gap between Pharmaceutical Development and Population Health

Metabolomics, 2016, Tolstikov – Metabolomic analysis is essential in the development of personalized, precision medicine Author: Tolstikov Vladimir In this review article, Dr. Vladimir Tolstikov, Berg’s Director of Metabolomics, discusses the current state and trends of metabolomics applications in pharmaceutical development, and highlights the importance of clinical metabolomics in precision medicine.  Metabolomics is the quantitative and…

Microbiota-driven Transcriptional Changes in Prefrontal Cortex Override Genetic Differences in Social Behavior

eLife, 2016, Gacias et al  Berg’s OMICS platform supports a link between gut metabolomic alterations and neurological function in collaboration with Mount Sinai School of Medicine Authors: Gacias M, Gaspari S, Santos PM, Tamburini S, Andrade M, Zhang F, Shen N, Tolstikov V, Kiebish MA, Dupree JL, Zachariou V, Clemente JC, Casaccia P Gene-environment interactions impact the development of neuropsychiatric disorders, such as autism, anxiety, and depression, but…

The Total and Mitochondrial Lipidome of Artemia franciscana encysted embryos

BBA- Molecular and Cell Biology of Lipids, 2016, Chen et al BERG collaborates with Semmelweis University on lipidomic analysis of the mitochondrial outer and inner membranes Authors:Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C Organisms are composed of multiple cellular and intracellular membranes, which have a unique lipid structure associated with…

Monoacylglycerol Analysis Using MS/MSALL Quadruple Time of Flight Mass Spectrometry

Metabolites, 2016, Gao et al BERG develops facile method for detecting and quantifying monoacylglycerols, which are potent signaling and precursor molecules. Authors: Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA Monoacylglycerols (MAGs) represent a critical intermediate in metabolism, however, MAGs have been very difficult to detect using robust mass spectrometry based methods.  To…

Dynamic Assessment of Functional Lipidomic Analysis in Human Urine

Lipids, 2016, Rockwell et al Berg develops a method for the analysis of lipid profiles in human biofluids for precision medicine applications Authors: Rockwell HE, Gao F, Chen EY, McDaniel J, Sarangarajan R, Narain NR, Kiebish MA Urine is a non-invasive biofluid that can be used to examine an individual’s physical state during diagnosis and disease monitoring. Development of analytical techniques to…

Reduced Expression of Collagen VI Alpha 3 (COL6A3) Confers Resistance to Inflammation-Induced MCP1 Expression in Adipocytes

Obesity, 2016, Gesta et al Reduction of COL6A3, a novel target discovered by Berg’s Interrogative Biology platform, protects against inflammation associated with obesity Authors: Gesta S, Guntur K, Majumdar ID, Akella S, Vishnudas VK, Sarangarajan R, Narain NR Inflammation of fat tissue has been associated with systemic metabolic abnormalities in patients with obesity. In fat tissue, collagen VI, which consists of three…