Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips

Metabolites, 2017 7(3), 35. BERG developed dried blood spot and dried urine strip workflow using metabolomics platform for potential precision medicine and population health applications. Authors: Jeremy Drolet, Vladimir Tolstikov, Brian Williams, Bennett Greenwood, Collin Hill, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish Analysis of a patient and population’s metabolic…

Blood sampled through dried blood spots (DBS) exhibits diminished ex vivo metabolism compared to whole blood through use of a kinetic isotope-labeling metabolomics approach

Biochemistry and Analytical Biochemistry, 2017, 6:2. BERG researchers investigate alternative methods for assessing metabolism in biofluids using an isotope labeling metabolomics approach through dried blood spot analysis. Authors: Collin Hill, Jeremy Drolet, Mark Kellogg, Vladimir Tolstikov, Niven R. Narain, and Michael A. Kiebish Analysis of metabolism in biofluids is a popular method for diagnosis and…

Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer

Journal of Molecular Biomarkers and Diagnosis, 2017, 8:2, 323. Ravipaty, et al. BERG, LLC, collaborated with Mount Sinai Hospital Toronto to develop and test a novel serum protein panel of three prostate cancer biomarkers for use in prostate cancer screening and diagnosis. Authors: Shobha Ravipaty, Wenfang Wu, Aditee Dalvi, Nikunj Tanna, Joe Andreazi, Tracey Friss,…

CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density

Biochimica et Biophysica Acta, 2017. Garg, et al. BERG, LLC, investigated the biophysical properties of BPM31510, a compound currently in clinical trials for cancer, and demonstrated that the selective incorporation of BPM31510 into cancer cells is dependent upon the lipid density of the cell membrane. Authors: Sumit Garg, Vandana Swaminathan, Sirisha Dhavala, Michael A. Kiebish, Rangaprasad…

Dynamic and temporal assessment of human dried blood spot MS/MS shotgun lipidomics analysis

Nutrition and Metabolism, 2017, 14: 28. Gao, et al. BERG, LLC, develops a novel mass spectrometry-based method to analyze lipid species from dried blood spot cards which can be used for precision medicine applications and in population health studies. Authors: Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir…

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017, Dowal, et al. BERG, LLC, demonstrates that white adipose tissue and macrophages are connected to the induction of low-grade inflammation, whereas brown adipose tissue and macrophages are not; introducing the possibility of exploring brown adipose tissue directed therapies for obesity-associated inflammatory diseases. Authors: Louisa Dowal, Pooja Parameswaran, Sarah Phat, Syamala Akella,…

Clinical Metabolomics: A Pivotal Tool for Companion Diagnostic Development and Precision Medicine

Expert Reviews of Molecular Diagnostics, Vol 17, 2017, Tolstikov, et al. – Metabolomics is an essential component of a precision medicine-based strategy for diagnostic and disease therapy. Authors: Vladimir Tolstikov, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish Companion diagnostics are useful in determining a positive or negative response to a…

Predicting Prostate Cancer Progression as a Function of ERG Status, Race & Obesity in a Longitudinal Patient Cohort

European Urology Focus 2017, Cullen et al. – BERG, LLC, collaborates with the Walter Reed National Military Medical Center and Center for Prostate Disease Research (CPDR) to investigate a large, racially diverse military population demonstrating that ERG tumor gene expression is a useful predictor of progression amongst Caucasian patients, but not for African Americans. Authors: Jennifer…

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017, May et al.- BERG collaborates with Joslin Diabetes Center, Boston, to characterize the lipidome of white and brown adipose tissue in response to exercise Francis J. May, Lisa A. Baer, Adam C. Lehnig, Kawai So, Emily Y. Chen, Fei Gao, Niven R. Narain, Liubov Gushchina, Aubrey Rose, Andrea I. Doseff, Michael A.…

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

Journal of Extracellular Vesicles, 2016, Haraszti et al – BERG collaborates with UMASS School of Medical to characterize the lipidome of exosomes and microvesicles Authors: Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin, and Anastasia Khvorova Exosomes and microvesicles represent a novel biological mechanism of communication between…
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