Monoacylglycerol Analysis Using MS/MSALL Quadruple Time of Flight Mass Spectrometry

Metabolites, 2016, Gao et al BERG develops facile method for detecting and quantifying monoacylglycerols, which are potent signaling and precursor molecules.

Authors: Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA

Monoacylglycerols (MAGs) represent a critical intermediate in metabolism, however, MAGs have been very difficult to detect using robust mass spectrometry based methods.  To allow for easy analysis of MAGs in clinical samples, BERG developed a rapid and robust high resolution MS/MSALL shotgun lipidomics workflow to capture these critical molecules in biofluid and tissue samples in collaboration with Harvard Medical School and Joslin Diabetes Center.  By allowing for easy detection of MAGs, we now can advance our understanding of their role in the pathogenesis of cancers, metabolic diseases, inflammation, and other diseases associated with disturbances in MAG.